PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4098)
Related Products (4098)
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PROTAC Linkers Isoform Comparison
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Fmoc-N-amido-PEG4-amine
0 ImagesCat. No.: HY-134715CAS No.: 2709328-44-7
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Bromo-PEG8-CH2COOtBu
0 ImagesCat. No.: HY-144078CAS No.: 2766000-38-6
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Boc-Aminooxy-PEG4-CH2CO2H
0 ImagesCat. No.: HY-140416CAS No.: 2028281-90-3
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t-Boc-N-amido-PEG6-Tos
0 ImagesCat. No.: HY-W096165CAS No.: 1264015-76-0
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Carboxy-PEG2-sulfonic acid
0 ImagesCat. No.: HY-140167CAS No.: 1817735-45-7
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Bromoacetamido-PEG8-Boc
0 ImagesCat. No.: HY-141389CAS No.: 2055041-16-0
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N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester
0 ImagesCat. No.: HY-140094CAS No.: 2093152-78-2N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Active-mono-sulfone-PEG8-acid
0 ImagesCat. No.: HY-140513CAS No.: 2055048-45-6
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Boc-Pip-alkyne-Ph-COOH
0 ImagesCat. No.: HY-133044CAS No.: 2581824-70-4Boc-Pip-alkyne-Ph-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-Pip-alkyne-Ph-COOH can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 effectively induces degradation of androgen receptor (AR) protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM. Boc-Pip-alkyne-Ph-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Azide-PEG6-Tos
0 ImagesAzide-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG6-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bromo-PEG3-THP
0 ImagesCat. No.: HY-132033CAS No.: 220568-33-2
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Boc-C1-PEG3-C4-OBn
0 ImagesCat. No.: HY-130619CAS No.: 2381196-81-0Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Fmoc-PEG6-NHS ester
0 ImagesCat. No.: HY-126882CAS No.: 1818294-31-3
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N-(Mal-PEG6)-N-bis(PEG7-TCO)
0 ImagesCat. No.: HY-141009CAS No.: 2093152-84-0N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Mal-PEG6)-N-bis(PEG7-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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(S,E)-TCO2-PEG8-acid
0 ImagesCat. No.: HY-141161A(S)-TCO-PEG8-acid is a click chemistry PEG linker with a terminal carboxylic acid(COOH) group. The terminal carboxylic acid is reactive with primary amine groups to form a stable amide bond. (S)-TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. (S)-TCO-PEG8-acid is longer than (S)-TCO-PEG3-acid.
